In Vitro Methods in Pharmaceutical ResearchJose V. Castell, Maria Jose Gmez-Lechn Elsevier, 1996. 10. 4. - 467페이지 In Vitro Methods in Pharmaceutical Research provides a comprehensive guide to laboratory techniques for evaluating in vitro organ toxicity using cellular models. Step-by-step practical tips on how to perform and interpret assays for drug metabolism and toxicity assessment are provided, along with a comparison of different techniques available. It is a welcome addition to the literature at a time when interest is growing in cellular in vitro models for toxicology and pharmacology studies. - Meets the continuing demand for information in this field - Compares In Vitro techniques with other methods - Describes cell-culture methods used to investigate toxicity in cells derived from different organs - Includes contributions by leading experts in the field |
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acid activity adducts animals apoptosis assessment Biochem Biol biotransformation Ca2+ calcium cartilage cell culture cell lines cell types cellular chemicals chondrocytes co-culture collagen compounds concentration culture medium cytochrome P450 cytokines cytotoxicity damage differentiation Draize eye test drug metabolism effects embryo end-points enzymes epidermis epithelial cells evaluation exposure expression eye irritation fibroblasts fluorescence function gene genotoxicity glutathione Gómez-Lechón growth factor hepatic hepatocytes hepatotoxicity human hepatocytes human liver incubation induced inhibition intracellular isolated keratinocytes kidney lipid peroxidation liver liver slices mammalian measured mechanisms mechanistic membrane metabolites microsomes mitochondrial molecular monolayer mRNA Mutagen mutation myocytes nephrotoxicity neurones ocular oxidative oxygen parameters perfusion pharmaceutical Pharmacol photosensitization phototoxicity potential predictive primary culture protein proteoglycan proximal tubule QSAR rabbit rat hepatocytes renal response screening sensitive skin specific studies synthesis teratogenic tissue Toxicol Toxicology uptake vitro assays vitro methods vitro systems vitro tests vivo xenobiotics
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10 페이지 - An experiment shall not be performed if another scientifically satisfactory method of obtaining the result sought, not entailing the use of an animal, is reasonably and practicably available.