Bioinformatics and Functional Genomics

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John Wiley & Sons, 2005. 3. 4. - 792페이지
Wiley is proud to announce the publication of the first ever broad-based textbook introduction to Bioinformatics and Functional Genomics by a trained biologist, experienced researcher, and award-winning instructor. In this new text, author Jonathan Pevsner, winner of the 2001 Johns Hopkins University "Teacher of the Year" award, explains problem-solving using bioinformatic approaches using real examples such as breast cancer, HIV-1, and retinal-binding protein throughout. His book includes 375 figures and over 170 tables. Each chapter includes: Problems, discussion of Pitfalls, Boxes explaining key techniques and math/stats principles, Summary, Recommended Reading list, and URLs for freely available software. The text is suitable for professionals and students at every level, including those with little to no background in computer science.

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PART II GENOMEWIDE ANALYSIS OF RNA AND PROTEIN
155
PART III GENOME ANALYSIS
395
Epilogue
695
Appendix GCG for Protein and DNA Analysis
697
Glossary
717
Solutions to SelfTest Quizzes
735
Subject Index
737
Author Index
753
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356 페이지 - As many more individuals of each species are born than can possibly survive; and as, consequently, there is a frequently recurring struggle for existence, it follows that any being, if it vary however slightly in any manner profitable to itself, under the complex and sometimes varying conditions of life, will have a better chancs of surviving, and thus be naturally selected.
185 페이지 - Brazma, A., Hingamp, P., Quackenbush, J., Sherlock, G., Spellman, P., Stoeckert, C., Aach, J., Ansorge, W., Ball, CA, Causton, HC...
396 페이지 - ... branches of various sizes may represent those whole orders, families, and genera which have now no living representatives, and which are known to us only in a fossil state.
396 페이지 - As buds give rise by growth to fresh buds, and these, if vigorous, branch out and overtop on all sides many a feebler branch, so by generation I believe it has been with the great Tree of Life, which fills with its dead and broken branches the crust of the earth, and covers the surface with its ever-branching and beautiful ramifications.
722 페이지 - Gene The fundamental physical and functional unit of heredity. A gene is an ordered sequence of nucleotides located in a particular position on a particular chromosome that encodes a specific functional product (ie, a protein or RNA molecule).
396 페이지 - The green and budding twigs may represent existing species ; and those produced during each former year may represent the long succession of extinct species. At each period of growth, all the growing twigs have tried to branch out on all sides, and to overtop and Kill the surrounding twigs and branches, in the same manner as species and groups of species have tried to overmaster other species in the great battle for life.
219 페이지 - Lewis DB, Tibshirani R, Sherlock G, Chan WC, Greiner TC, Weisenburger DD, Armitage JO, Warnke R, Staudt LM, et al. (2000). Distinct types of diffuse large B-cell lymphoma identified by gene expression profiling.
464 페이지 - Invertebrata) their incredible numbers, their universal distribution, their insatiable voracity, and that it is the particles of decaying vegetable and animal bodies which they are appointed to devour and assimilate. Surely we must in some degree be indebted to these ever-active invisible scavengers, for the salubrity of our atmosphere. Nor is this all : they perform a still more important office in preventing the gradual diminution of the present amount of organized matter upon the earth.
396 페이지 - The limbs divided into great branches, and these into lesser and lesser branches, were themselves once, when the tree was small, budding twigs ; and this connexion of the former and present buds by ramifying branches may well represent the classification of all extinct and living species in groups subordinate to groups.
396 페이지 - The affinities of all the beings of the same class have sometimes been represented by a great tree. I believe this simile largely speaks the truth.

저자 정보 (2005)

Jonathan Pevsner received his Ph.D. in Pharmacology and Molecular Sciences at the Johns Hopkins School of Medicine (1989). There, he identified an odorant-binding protein in nasal secretions. He completed postdoctoral training as a Helen Hay Whitney fellow in the Department of Molecular Physiology at the Stanford University Medical Center. At Stanford he identified proteins that function in neurotransmitter release at nerve terminals. In 1995 he joined the faculty in the Department of Neurology at the Kennedy Krieger Institute and the Department of Neuroscience at the Johns Hopkins School of Medicine. He began teaching bioinformatics in 1996, and introduced a ten-week course in 2000. In 2001 the graduate students voted him Teacher of the Year, and in 2003 the Johns Hopkins faculty gave him the Professor’s Award for Excellence in Teaching. His lab studies the molecular basis of childhood neurological disorders including autism and Down Syndrome, and develops bioinformatics software.

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