Animal Test Alternatives: Refinement, Reduction, ReplacementHarry Salem M. Dekker, 1995 - 349페이지 Over 75 contributors from industry, academia, and government evaluate the latest developments and possible directions in alternatives to using animals in research and testing, and explain the regulatory climate that surrounds the controversial topic. Among the alternatives described are computer and chemical models, cell and tissue cultures, and the substitution of animals lower on the phylogenetic genetic tree that are neither cute nor fuzzy. The research considered involves such systems as the ocular, hepatic, renal, respiratory, cardiovascular, and environmental. Annotation c. by Book News, Inc., Portland, Or. |
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The Evolution of In Vitro Toxicology in the Pharmaceutical | 1 |
The Use of Theoretical Descriptors in Quantitative Structure | 27 |
Experimentally Derived Values with StructureActivity | 37 |
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Aberdeen Proving Ground alternative alveolar macrophages animal testing Appl assay assessment biochemical biological carcinogenesis cell culture cellular Chem compounds concentration contact dermatitis correlation cosmetics cyanide cytotoxicity dermal irritation descriptors determined developmental toxicity dose dose-response Draize Drug effects embryos endpoints Environmental epidermal epithelial cells evaluated exposed exposure FETAX fibers fluorescence growth factor hemocyte hepatocytes human increase incubation inhalation inhibition interactions Interleukin-1 irritation test isolated Kevlar Laboratory liver lung macrophages Mary Ann Liebert Maryland mechanisms medium membrane metabolites methods molecular Non-PI Non-PI Pharmacol photoirritant potential predict primate hepatocytes proliferation protein pulmonary QSAR quantitative rabbit rat hepatocytes reactive receptor release Research respiratory response RTE cells screening skin specific structure studies target teratogen teratogenesis test chemical test system tion tissue toxicity toxicity tests Toxicol tracheal U.S. Army uptake UVA Non-PI UVA PI validation verapamil vitro models vitro systems vitro tests Vitro Toxicology vivo µg/ml